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CRA_Updated_Version/CRA_Toolbox_bash/Examples/parameters_EGFR_IGF1R_model.m

+% Model parameters 
+
+gamma_EGFR=0.02;
+gamma_IGF1R=0.02;
+kd_PIK3_active=0.005;
+k_p90Rsk_Erk=0.0213697;
+KM_p90Rsk_Erk=763523;
+k_SOS_EGFR=694.731;
+KM_SOS_EGFR=6086070;
+k_Ras_SOS=32.344;
+KM_Ras_SOS=35954.3;
+k_ERK_MEK=9.85367;
+KM_ERK_MEK=1007340;
+k_DSOS_p90Rsk=161197;
+KM_DSOS_p90Rsk=896896;
+k_SOS_IGF1R=500;
+KM_SOS_IGF1R=100000;
+k_PIK3_IGF1R=10.6737;
+KM_PIK3_IGF1R=184912;
+k_PIK3_EGFR=10.6737;
+KM_PIK3_EGFR=184912;
+k_Akt_PIK3=0.0566279;
+KM_Akt_PIK3=653951;
+kd_Akt=0.005;
+k_Erk_PP2A=9.85367;
+KM_Erk_PP2A=1007340;
+k_PIK3_Ras=0.0771067;
+KM_PIK3_Ras=272056;
+k_Raf_Ras=0.884096;
+KM_Raf_Ras=62464.6;
+k_Mek_Raf=185.759;
+KM_Mek_Raf=4768350;
+k_Raf_Akt=15.1212;
+KM_Raf_Akt=119355;
+k_Ras_RasGab=1509.36;
+KM_Ras_RasGab=1432410;
+k_MEK_PP2A=2.83243;
+KM_MEK_PP2A=518753;
+k_Raf_RafPP=0.126329;
+KM_Raf_RafPP=1061.71;
+kd_P90Rsk=0.005;
+
+
+% Input values
+RafPP=120000;
+PP2A=120000;
+RasGapActive=120000;
+
+
+
+% Total concentrations
+DSOS_tot=120000.0;
+Ras_tot=120000.0;
+Raf_tot=120000.0;
+Mek_tot=600000.0;
+Erk_tot=600000.0;
+p90Rsk_tot=120000.0;
+PIK3_tot=120000.0;
+Akt_tot=120000.0;
+
+
+% Initial conditions for state variables 
+EGFR_active_0=8000.0;
+IGF1R_active_0=650.0;
+SOS_0=0.0;
+Ras_active_0=0.0;
+Raf_active_0=0.0;
+Mek_active_0=0.0;
+Erk_active_0=0.0;
+p90Rsk_active_0=0.0;
+PIK3_active_0=0.0;
+Akt_active_0=0.0;
+
+
+
+