Commit f7025376 by Chiara Antonini

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1 parent 46a5ca2e
% Model parameters
gamma_EGFR=0.02;
gamma_IGF1R=0.02;
kd_PIK3_active=0.005;
k_p90Rsk_Erk=0.0213697;
KM_p90Rsk_Erk=763523;
k_SOS_EGFR=694.731;
KM_SOS_EGFR=6086070;
k_Ras_SOS=32.344;
KM_Ras_SOS=35954.3;
k_ERK_MEK=9.85367;
KM_ERK_MEK=1007340;
k_DSOS_p90Rsk=161197;
KM_DSOS_p90Rsk=896896;
k_SOS_IGF1R=500;
KM_SOS_IGF1R=100000;
k_PIK3_IGF1R=10.6737;
KM_PIK3_IGF1R=184912;
k_PIK3_EGFR=10.6737;
KM_PIK3_EGFR=184912;
k_Akt_PIK3=0.0566279;
KM_Akt_PIK3=653951;
kd_Akt=0.005;
k_Erk_PP2A=9.85367;
KM_Erk_PP2A=1007340;
k_PIK3_Ras=0.0771067;
KM_PIK3_Ras=272056;
k_Raf_Ras=0.884096;
KM_Raf_Ras=62464.6;
k_Mek_Raf=185.759;
KM_Mek_Raf=4768350;
k_Raf_Akt=15.1212;
KM_Raf_Akt=119355;
k_Ras_RasGab=1509.36;
KM_Ras_RasGab=1432410;
k_MEK_PP2A=2.83243;
KM_MEK_PP2A=518753;
k_Raf_RafPP=0.126329;
KM_Raf_RafPP=1061.71;
kd_P90Rsk=0.005;
% Input values
RafPP=120000;
PP2A=120000;
RasGapActive=120000;
% Total concentrations
DSOS_tot=120000.0;
Ras_tot=120000.0;
Raf_tot=120000.0;
Mek_tot=600000.0;
Erk_tot=600000.0;
p90Rsk_tot=120000.0;
PIK3_tot=120000.0;
Akt_tot=120000.0;
% Initial conditions for state variables
EGFR_active_0=8000.0;
IGF1R_active_0=650.0;
SOS_0=0.0;
Ras_active_0=0.0;
Raf_active_0=0.0;
Mek_active_0=0.0;
Erk_active_0=0.0;
p90Rsk_active_0=0.0;
PIK3_active_0=0.0;
Akt_active_0=0.0;
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