Skip to content

SysBiOThe / CRA-Matlab

Go to a project
Toggle navigation
Toggle navigation pinning
Commit 6f685b64 by Chiara Antonini
Options

matlab code

1 parent 45ea315f
Inline Side-by-side
Showing 6 changed files with 1236 additions and 0 deletions
Models/EGFR_IG1FRmodel.sbproj 0 → 100644
No preview for this file type
Models/EGFR_IG1FRmodel.xml 0 → 100644
<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Version Major="5" Minor="0" Point="0"/>
</SimBiology>
</annotation>
<model id="mwb28c663b_ca84_47a4_a01f_ab2ef89dd511" name="EGFR_IGF1Rmodel">
<listOfCompartments>
<compartment id="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" name="unnamed" size="1"/>
</listOfCompartments>
<listOfSpecies>
<species id="mw20a3c243_1ac5_4aec_bf03_2c4554ab4975" name="EGFR_active" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="8000"/>
<species id="mwc46f130c_490a_4ace_ac22_1fe7e6157036" name="IGFR_active" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="650"/>
<species id="mwb8aa1a3a_08eb_446a_a4be_73935d0d11a3" name="SOS" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="120000"/>
<species id="mwdabb1949_c6b6_4fdc_9748_18465ef4fcca" name="SOS_active" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="0"/>
<species id="mw39701dcf_5a00_4033_903a_886f8b7020e7" name="p90Rsk_active" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="0"/>
<species id="mwd31e0c7c_2c4f_42cd_866a_50c7f2e91cc3" name="Ras" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="120000"/>
<species id="mw556671c8_b97d_4fdd_8af3_f35279f6e3f5" name="Ras_active" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="0"/>
<species id="mw557c1d23_ed5f_4cf9_860a_dc12cdd20ad9" name="RasGapActive" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="120000" constant="true"/>
<species id="mw1575ced0_7ec6_40de_83a1_eb51e7de9ba4" name="Raf" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="120000"/>
<species id="mwa99f02ec_f6e7_4ea3_ac03_ef1a56eb004f" name="Raf_active" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="0"/>
<species id="mwf347199a_83ed_48d4_955a_1ad01b8f297c" name="RafPP" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="120000" constant="true"/>
<species id="mw36b3b202_3410_404b_98c1_60a2e5897464" name="Akt_active" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="0"/>
<species id="mw62f46ed4_cfd5_4fde_8ee9_0b9983a36735" name="Mek" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="600000"/>
<species id="mwa941decf_db08_46c3_ac49_2f5cac8e8d00" name="Mek_active" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="0"/>
<species id="mw4e61698f_a9e9_483d_a518_97ffb34605ac" name="PP2A" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="120000" constant="true"/>
<species id="mwd580befa_cb2d_42af_a2e2_28c373e44055" name="Erk" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="600000"/>
<species id="mw57643b75_791d_4457_8e6c_6424ba634388" name="Erk_active" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="0"/>
<species id="mwd3ce0244_3dca_4cf7_bc64_fa03f092a39d" name="p90Rsk" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="120000"/>
<species id="mw8a15ca30_1023_4185_a3b7_4c55bf741205" name="PIK3" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="120000"/>
<species id="mw3516e900_2646_47af_bbb0_20aceee12e72" name="PIK3_active" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="0"/>
<species id="mwbf97d29f_a5bc_41f4_b32d_aef51421301e" name="Akt" compartment="mwa4d588fc_128f_4b33_afb8_13a44518c5ed" initialAmount="120000"/>
</listOfSpecies>
<listOfParameters>
<parameter id="mwb3be9ad4_75ee_4f50_a0bd_cbe3893771da" name="KM_DSOS_p90Rsk" value="896896"/>
<parameter id="mwd5051288_ffc3_4c7e_a914_3eec94a67b50" name="k_DSOS_p90Rsk" value="161197"/>
<parameter id="mwdaa92f4e_b94f_47c3_936f_684bd6901f87" name="KM_SOS_IGFR" value="1000000"/>
<parameter id="mwe50aef92_6248_40c0_8ef8_1055cd478a5e" name="k_SOS_IGFR" value="500"/>
<parameter id="mw97053d3e_fc54_48b8_af2d_f01a0ff3b520" name="KM_SOS_EGFR" value="6086070"/>
<parameter id="mw3efdb8d8_c707_4e24_983a_15dc21fdce6d" name="k_SOS_EGFR" value="694.731"/>
<parameter id="mwcb8237d2_abff_4693_8fd2_8ba2269ee216" name="KM_Ras_RasGab" value="1432410"/>
<parameter id="mw35126e12_7bd4_41c6_8ee4_935962ef8e5b" name="k_Ras_RasGab" value="1509.36"/>
<parameter id="mwae9a6cdb_64a2_4ed4_8bc8_a906cafcd075" name="KM_Ras_SOS" value="35954.3"/>
<parameter id="mw152f7d7d_f4de_4138_98b7_b74738054ad5" name="k_Ras_SOS" value="32.344"/>
<parameter id="mwd501fc1a_74c2_4699_ad16_90785be82c09" name="k_Akt_PIK3" value="0.0566279"/>
<parameter id="mw74bbb675_5c3d_4710_a0e2_784315af0ed3" name="KM_Akt_PIK3" value="653951"/>
<parameter id="mwb9d7d58a_e5ba_40d8_b99c_b422f26acfb1" name="kd_Akt" value="0.005"/>
<parameter id="mw2747a280_f6f5_4f01_992d_078887ca047d" name="gamma_EGFR" value="0.02"/>
<parameter id="mwd6d64ead_3392_4524_83fc_61702503074d" name="k_Erk_Mek" value="9.85367"/>
<parameter id="mw9c7351cd_1a6b_4b8e_8b94_1a41d2941089" name="KM_Erk_Mek" value="1007340"/>
<parameter id="mw9cef71cc_1f87_4a98_ab99_746827592aa9" name="k_Erk_PP2A" value="9.85367"/>
<parameter id="mwf6575bbe_2339_4d03_aa45_45cfead6aeff" name="KM_Erk_PP2A" value="1007340"/>
<parameter id="mw33ad42f9_c52c_4a7f_b9f0_d096e9bc2dde" name="gamma_IGFR" value="0.02"/>
<parameter id="mwecc3342f_6637_426a_8a89_13663f95ac9a" name="k_Mek_Raf" value="185.759"/>
<parameter id="mw442f6916_de12_432c_8894_1a0f5689cd8b" name="KM_Mek_Raf" value="4768350"/>
<parameter id="mw948db626_c7a4_4884_83e0_0c3a724c134b" name="k_Mek_PP2A" value="2.83243"/>
<parameter id="mw7c24d08b_34c8_4cb8_89b8_d5bacf81068c" name="KM_Mek_PP2A" value="518753"/>
<parameter id="mw850a4bd2_7343_449c_b024_f434843fd043" name="k_p90Rsk_Erk" value="0.0213697"/>
<parameter id="mw8be5b73b_3551_4cf5_8e3b_e70f1f90fb04" name="KM_p90Rsk_Erk" value="763523"/>
<parameter id="mwffd3777d_62cb_4e16_b602_caef537b56c5" name="kd_p90Rsk" value="0.005"/>
<parameter id="mw6f50947f_1189_441c_ab6d_638c67d611a3" name="k_PIK3_IGFR" value="10.6737"/>
<parameter id="mw9c40fc53_6e35_49d4_abc1_4803feaa0306" name="KM_PIK3_IGFR" value="184912"/>
<parameter id="mw4569b23f_a246_42fc_b873_0113c46d6777" name="k_PIK3_EGFR" value="10.6737"/>
<parameter id="mw925fdda5_e449_494d_b548_d18e8887445e" name="KM_PIK3_EGFR" value="184912"/>
<parameter id="mw3b05e6b0_f404_4b29_9f69_9196f1862056" name="k_PIK3_Ras" value="0.0771067"/>
<parameter id="mwca4c5ded_ea90_4a7b_90b1_c0c9b0f87a7d" name="KM_PIK3_Ras" value="272056"/>
<parameter id="mw5fdf5881_e3d5_4f46_aec5_370bcf6a9bba" name="kd_PIK3_active" value="0.005"/>
<parameter id="mw9cf2373c_7bec_44b6_b614_3bda906ac9bf" name="k_Raf_Ras" value="0.884096"/>
<parameter id="mw099f8c81_8236_4d98_835f_c83244ac8be2" name="KM_Raf_Ras" value="62464.6"/>
<parameter id="mw2f89d540_2c71_44d3_b5fc_dcaae98afa34" name="k_Raf_RafPP" value="0.126329"/>
<parameter id="mw0108bdd0_6bdc_484f_b24c_79eada3e55d3" name="KM_Raf_RafPP" value="1061.71"/>
<parameter id="mwc191c388_de3f_48a9_90fc_545016885872" name="k_Raf_Akt" value="15.1212"/>
<parameter id="mw82558f30_bde6_421b_9f0e_b8e700908da6" name="KM_Raf_Akt" value="119355"/>
</listOfParameters>
<listOfReactions>
<reaction id="mw1de21c5e_a00e_49d8_b586_bf464e82af81" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mw20a3c243_1ac5_4aec_bf03_2c4554ab4975"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw2747a280_f6f5_4f01_992d_078887ca047d </ci>
<ci> mw20a3c243_1ac5_4aec_bf03_2c4554ab4975 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw677125b9_e098_4a0d_9d5f_5834a5e3c48b" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mwc46f130c_490a_4ace_ac22_1fe7e6157036"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw33ad42f9_c52c_4a7f_b9f0_d096e9bc2dde </ci>
<ci> mwc46f130c_490a_4ace_ac22_1fe7e6157036 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw1925790a_9952_47c4_91ff_72c0f602b2e8" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mwb8aa1a3a_08eb_446a_a4be_73935d0d11a3"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwdabb1949_c6b6_4fdc_9748_18465ef4fcca"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mw3efdb8d8_c707_4e24_983a_15dc21fdce6d </ci>
<ci> mw20a3c243_1ac5_4aec_bf03_2c4554ab4975 </ci>
<ci> mwb8aa1a3a_08eb_446a_a4be_73935d0d11a3 </ci>
</apply>
<apply>
<plus/>
<ci> mw97053d3e_fc54_48b8_af2d_f01a0ff3b520 </ci>
<ci> mwb8aa1a3a_08eb_446a_a4be_73935d0d11a3 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwd75f4628_8b14_4c73_97e5_c8d20bf1247b" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mwb8aa1a3a_08eb_446a_a4be_73935d0d11a3"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwdabb1949_c6b6_4fdc_9748_18465ef4fcca"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mwe50aef92_6248_40c0_8ef8_1055cd478a5e </ci>
<ci> mwc46f130c_490a_4ace_ac22_1fe7e6157036 </ci>
<ci> mwb8aa1a3a_08eb_446a_a4be_73935d0d11a3 </ci>
</apply>
<apply>
<plus/>
<ci> mwdaa92f4e_b94f_47c3_936f_684bd6901f87 </ci>
<ci> mwb8aa1a3a_08eb_446a_a4be_73935d0d11a3 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw5aaabd36_ba2f_4303_bc69_c22638020886" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mwdabb1949_c6b6_4fdc_9748_18465ef4fcca"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwb8aa1a3a_08eb_446a_a4be_73935d0d11a3"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mwd5051288_ffc3_4c7e_a914_3eec94a67b50 </ci>
<ci> mw39701dcf_5a00_4033_903a_886f8b7020e7 </ci>
<ci> mwdabb1949_c6b6_4fdc_9748_18465ef4fcca </ci>
</apply>
<apply>
<plus/>
<ci> mwb3be9ad4_75ee_4f50_a0bd_cbe3893771da </ci>
<ci> mwdabb1949_c6b6_4fdc_9748_18465ef4fcca </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwe9a327d0_457b_422e_a7b2_0c81147de36e" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mwd31e0c7c_2c4f_42cd_866a_50c7f2e91cc3"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw556671c8_b97d_4fdd_8af3_f35279f6e3f5"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mw152f7d7d_f4de_4138_98b7_b74738054ad5 </ci>
<ci> mwdabb1949_c6b6_4fdc_9748_18465ef4fcca </ci>
<ci> mwd31e0c7c_2c4f_42cd_866a_50c7f2e91cc3 </ci>
</apply>
<apply>
<plus/>
<ci> mwae9a6cdb_64a2_4ed4_8bc8_a906cafcd075 </ci>
<ci> mwd31e0c7c_2c4f_42cd_866a_50c7f2e91cc3 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw5c81f6d6_dfca_4350_b5ac_2999ec7f8372" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mw556671c8_b97d_4fdd_8af3_f35279f6e3f5"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwd31e0c7c_2c4f_42cd_866a_50c7f2e91cc3"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mw35126e12_7bd4_41c6_8ee4_935962ef8e5b </ci>
<ci> mw557c1d23_ed5f_4cf9_860a_dc12cdd20ad9 </ci>
<ci> mw556671c8_b97d_4fdd_8af3_f35279f6e3f5 </ci>
</apply>
<apply>
<plus/>
<ci> mwcb8237d2_abff_4693_8fd2_8ba2269ee216 </ci>
<ci> mw556671c8_b97d_4fdd_8af3_f35279f6e3f5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw3c16501e_a442_42a4_97b8_9576cba03607" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mw1575ced0_7ec6_40de_83a1_eb51e7de9ba4"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwa99f02ec_f6e7_4ea3_ac03_ef1a56eb004f"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mw9cf2373c_7bec_44b6_b614_3bda906ac9bf </ci>
<ci> mw556671c8_b97d_4fdd_8af3_f35279f6e3f5 </ci>
<ci> mw1575ced0_7ec6_40de_83a1_eb51e7de9ba4 </ci>
</apply>
<apply>
<plus/>
<ci> mw099f8c81_8236_4d98_835f_c83244ac8be2 </ci>
<ci> mw1575ced0_7ec6_40de_83a1_eb51e7de9ba4 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwd132e5cc_8278_4a1e_b7df_6b53db9421f6" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mwa99f02ec_f6e7_4ea3_ac03_ef1a56eb004f"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw1575ced0_7ec6_40de_83a1_eb51e7de9ba4"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mw2f89d540_2c71_44d3_b5fc_dcaae98afa34 </ci>
<ci> mwf347199a_83ed_48d4_955a_1ad01b8f297c </ci>
<ci> mwa99f02ec_f6e7_4ea3_ac03_ef1a56eb004f </ci>
</apply>
<apply>
<plus/>
<ci> mw0108bdd0_6bdc_484f_b24c_79eada3e55d3 </ci>
<ci> mwa99f02ec_f6e7_4ea3_ac03_ef1a56eb004f </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw78c1f784_1233_41d8_be16_b43b73c1ef2e" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mwa99f02ec_f6e7_4ea3_ac03_ef1a56eb004f"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw1575ced0_7ec6_40de_83a1_eb51e7de9ba4"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mwc191c388_de3f_48a9_90fc_545016885872 </ci>
<ci> mw36b3b202_3410_404b_98c1_60a2e5897464 </ci>
<ci> mwa99f02ec_f6e7_4ea3_ac03_ef1a56eb004f </ci>
</apply>
<apply>
<plus/>
<ci> mw82558f30_bde6_421b_9f0e_b8e700908da6 </ci>
<ci> mwa99f02ec_f6e7_4ea3_ac03_ef1a56eb004f </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwd18e5168_12ec_44c8_a2fd_6597a9666745" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mw62f46ed4_cfd5_4fde_8ee9_0b9983a36735"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwa941decf_db08_46c3_ac49_2f5cac8e8d00"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mwecc3342f_6637_426a_8a89_13663f95ac9a </ci>
<ci> mwa99f02ec_f6e7_4ea3_ac03_ef1a56eb004f </ci>
<ci> mw62f46ed4_cfd5_4fde_8ee9_0b9983a36735 </ci>
</apply>
<apply>
<plus/>
<ci> mw442f6916_de12_432c_8894_1a0f5689cd8b </ci>
<ci> mw62f46ed4_cfd5_4fde_8ee9_0b9983a36735 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwe0a6be26_438c_4a96_bb1f_d15edca8d7ba" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mwa941decf_db08_46c3_ac49_2f5cac8e8d00"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw62f46ed4_cfd5_4fde_8ee9_0b9983a36735"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mw948db626_c7a4_4884_83e0_0c3a724c134b </ci>
<ci> mw4e61698f_a9e9_483d_a518_97ffb34605ac </ci>
<ci> mwa941decf_db08_46c3_ac49_2f5cac8e8d00 </ci>
</apply>
<apply>
<plus/>
<ci> mw7c24d08b_34c8_4cb8_89b8_d5bacf81068c </ci>
<ci> mwa941decf_db08_46c3_ac49_2f5cac8e8d00 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw242415d9_45f3_4730_bf68_4dba6b68c5e8" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mwd580befa_cb2d_42af_a2e2_28c373e44055"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw57643b75_791d_4457_8e6c_6424ba634388"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mwd6d64ead_3392_4524_83fc_61702503074d </ci>
<ci> mwa941decf_db08_46c3_ac49_2f5cac8e8d00 </ci>
<ci> mwd580befa_cb2d_42af_a2e2_28c373e44055 </ci>
</apply>
<apply>
<plus/>
<ci> mw9c7351cd_1a6b_4b8e_8b94_1a41d2941089 </ci>
<ci> mwd580befa_cb2d_42af_a2e2_28c373e44055 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw6af1bff6_279c_4e72_aceb_7ea77ae2e43e" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mw57643b75_791d_4457_8e6c_6424ba634388"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwd580befa_cb2d_42af_a2e2_28c373e44055"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mw9cef71cc_1f87_4a98_ab99_746827592aa9 </ci>
<ci> mw4e61698f_a9e9_483d_a518_97ffb34605ac </ci>
<ci> mw57643b75_791d_4457_8e6c_6424ba634388 </ci>
</apply>
<apply>
<plus/>
<ci> mwf6575bbe_2339_4d03_aa45_45cfead6aeff </ci>
<ci> mw57643b75_791d_4457_8e6c_6424ba634388 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwc00956ba_0932_4366_970e_48df5aa63040" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mwd3ce0244_3dca_4cf7_bc64_fa03f092a39d"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw39701dcf_5a00_4033_903a_886f8b7020e7"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mw850a4bd2_7343_449c_b024_f434843fd043 </ci>
<ci> mw57643b75_791d_4457_8e6c_6424ba634388 </ci>
<ci> mwd3ce0244_3dca_4cf7_bc64_fa03f092a39d </ci>
</apply>
<apply>
<plus/>
<ci> mw8be5b73b_3551_4cf5_8e3b_e70f1f90fb04 </ci>
<ci> mwd3ce0244_3dca_4cf7_bc64_fa03f092a39d </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw671aa14c_125b_4e5f_9104_8fc44960c235" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mw39701dcf_5a00_4033_903a_886f8b7020e7"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwd3ce0244_3dca_4cf7_bc64_fa03f092a39d"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwffd3777d_62cb_4e16_b602_caef537b56c5 </ci>
<ci> mw39701dcf_5a00_4033_903a_886f8b7020e7 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw181e82e3_78b4_465e_be31_15b7f8604a5e" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mw8a15ca30_1023_4185_a3b7_4c55bf741205"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw3516e900_2646_47af_bbb0_20aceee12e72"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mw6f50947f_1189_441c_ab6d_638c67d611a3 </ci>
<ci> mwc46f130c_490a_4ace_ac22_1fe7e6157036 </ci>
<ci> mw8a15ca30_1023_4185_a3b7_4c55bf741205 </ci>
</apply>
<apply>
<plus/>
<ci> mw9c40fc53_6e35_49d4_abc1_4803feaa0306 </ci>
<ci> mw8a15ca30_1023_4185_a3b7_4c55bf741205 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwedac3d01_97ad_4558_a3be_f2b3c044170b" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mw8a15ca30_1023_4185_a3b7_4c55bf741205"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw3516e900_2646_47af_bbb0_20aceee12e72"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mw4569b23f_a246_42fc_b873_0113c46d6777 </ci>
<ci> mw20a3c243_1ac5_4aec_bf03_2c4554ab4975 </ci>
<ci> mw8a15ca30_1023_4185_a3b7_4c55bf741205 </ci>
</apply>
<apply>
<plus/>
<ci> mw925fdda5_e449_494d_b548_d18e8887445e </ci>
<ci> mw8a15ca30_1023_4185_a3b7_4c55bf741205 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw8c7f6066_59ae_40c8_b425_b6cbdc8e2c33" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mw8a15ca30_1023_4185_a3b7_4c55bf741205"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw3516e900_2646_47af_bbb0_20aceee12e72"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mw3b05e6b0_f404_4b29_9f69_9196f1862056 </ci>
<ci> mw556671c8_b97d_4fdd_8af3_f35279f6e3f5 </ci>
<ci> mw8a15ca30_1023_4185_a3b7_4c55bf741205 </ci>
</apply>
<apply>
<plus/>
<ci> mwca4c5ded_ea90_4a7b_90b1_c0c9b0f87a7d </ci>
<ci> mw8a15ca30_1023_4185_a3b7_4c55bf741205 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw8d7fb3e5_434f_4ee8_a948_a890b901c74f" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mw3516e900_2646_47af_bbb0_20aceee12e72"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw8a15ca30_1023_4185_a3b7_4c55bf741205"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw5fdf5881_e3d5_4f46_aec5_370bcf6a9bba </ci>
<ci> mw3516e900_2646_47af_bbb0_20aceee12e72 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwe01bcb0d_3ad7_46fa_ac5b_31c2de5cc514" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mwbf97d29f_a5bc_41f4_b32d_aef51421301e"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mw36b3b202_3410_404b_98c1_60a2e5897464"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> mwd501fc1a_74c2_4699_ad16_90785be82c09 </ci>
<ci> mw3516e900_2646_47af_bbb0_20aceee12e72 </ci>
<ci> mwbf97d29f_a5bc_41f4_b32d_aef51421301e </ci>
</apply>
<apply>
<plus/>
<ci> mw74bbb675_5c3d_4710_a0e2_784315af0ed3 </ci>
<ci> mwbf97d29f_a5bc_41f4_b32d_aef51421301e </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw34576704_fdbb_4e68_896e_e83842379a38" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mw36b3b202_3410_404b_98c1_60a2e5897464"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="mwbf97d29f_a5bc_41f4_b32d_aef51421301e"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwb9d7d58a_e5ba_40d8_b99c_b422f26acfb1 </ci>
<ci> mw36b3b202_3410_404b_98c1_60a2e5897464 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>
Models/PulseGenerator.sbproj 0 → 100644
No preview for this file type
Models/PulseGenerator.xml 0 → 100644
<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Version Major="5" Minor="0" Point="0"/>
</SimBiology>
</annotation>
<model id="mw5e5242c9_f106_49c1_ad79_a05890c967e2" name="ReteSintetica">
<listOfCompartments>
<compartment id="mwa3854151_cd74_4ccb_9185_e480b212e53a" name="unnamed" size="1"/>
</listOfCompartments>
<listOfSpecies>
<species id="mwecf685eb_710c_458e_a826_ac4316797fec" name="R2_active" compartment="mwa3854151_cd74_4ccb_9185_e480b212e53a" initialAmount="0"/>
<species id="mw0769da31_7f58_4816_a3d5_89813f4ae836" name="S1" compartment="mwa3854151_cd74_4ccb_9185_e480b212e53a" initialAmount="470" boundaryCondition="true"/>
<species id="mw2cc70178_a739_438f_b5e7_d2ff73bc3376" name="Y_active" compartment="mwa3854151_cd74_4ccb_9185_e480b212e53a" initialAmount="0"/>
</listOfSpecies>
<listOfParameters>
<parameter id="mw6d98d26e_e7e9_4d97_8345_f82836972796" name="k1" value="5"/>
<parameter id="mwa02b0398_454f_4927_b65e_7cc91bf2bbdc" name="K1" value="1"/>
<parameter id="mwf11e97f2_87b4_40c3_8e01_06f18e79c7c7" name="k12" value="20"/>
<parameter id="mw12802443_ef80_47b5_8c03_a43aaf18515e" name="K2" value="100"/>
<parameter id="mwf52fa444_2fc9_4977_a76e_b7901005e084" name="lambda_2" value="0.01"/>
<parameter id="mw748972a5_3f1f_4c2a_a308_1fdf0f8fc959" name="lambda" value="0.04"/>
</listOfParameters>
<listOfReactions>
<reaction id="mw3f8353f6_d80b_45cf_916b_b27bd04aa9bd" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mwecf685eb_710c_458e_a826_ac4316797fec"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mwf52fa444_2fc9_4977_a76e_b7901005e084 </ci>
<ci> mwecf685eb_710c_458e_a826_ac4316797fec </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwd5e6bcfb_8775_4fe8_8ea4_7ebcf1262b7f" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mwecf685eb_710c_458e_a826_ac4316797fec"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw6d98d26e_e7e9_4d97_8345_f82836972796 </ci>
<apply>
<divide/>
<apply>
<power/>
<apply>
<divide/>
<ci> mw0769da31_7f58_4816_a3d5_89813f4ae836 </ci>
<ci> mwa02b0398_454f_4927_b65e_7cc91bf2bbdc </ci>
</apply>
<cn type="integer"> 3 </cn>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<power/>
<apply>
<divide/>
<ci> mw0769da31_7f58_4816_a3d5_89813f4ae836 </ci>
<ci> mwa02b0398_454f_4927_b65e_7cc91bf2bbdc </ci>
</apply>
<cn type="integer"> 3 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwa58b7194_967a_4057_81dd_cdd686063324" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="mw2cc70178_a739_438f_b5e7_d2ff73bc3376"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw748972a5_3f1f_4c2a_a308_1fdf0f8fc959 </ci>
<ci> mw2cc70178_a739_438f_b5e7_d2ff73bc3376 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwc152b0b4_94f2_475e_92fc_26eaee472a99" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mw2cc70178_a739_438f_b5e7_d2ff73bc3376"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<apply>
<divide/>
<ci> mwf11e97f2_87b4_40c3_8e01_06f18e79c7c7 </ci>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<power/>
<apply>
<divide/>
<ci> mwecf685eb_710c_458e_a826_ac4316797fec </ci>
<ci> mw12802443_ef80_47b5_8c03_a43aaf18515e </ci>
</apply>
<cn type="integer"> 3 </cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<power/>
<apply>
<divide/>
<ci> mw0769da31_7f58_4816_a3d5_89813f4ae836 </ci>
<ci> mwa02b0398_454f_4927_b65e_7cc91bf2bbdc </ci>
</apply>
<cn type="integer"> 3 </cn>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<power/>
<apply>
<divide/>
<ci> mw0769da31_7f58_4816_a3d5_89813f4ae836 </ci>
<ci> mwa02b0398_454f_4927_b65e_7cc91bf2bbdc </ci>
</apply>
<cn type="integer"> 3 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
</listOfReactions>
<listOfEvents>
<event id="mwb0716424_3762_425b_b959_3ca6703abfcb">
<trigger>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<geq/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<cn type="integer"> 50 </cn>
</apply>
</math>
</trigger>
<listOfEventAssignments>
<eventAssignment variable="mw0769da31_7f58_4816_a3d5_89813f4ae836">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</eventAssignment>
</listOfEventAssignments>
</event>
</listOfEvents>
</model>
</sbml>
Models/model_Peng2016_reduced.sbproj 0 → 100644
No preview for this file type
Models/model_Peng2016_reduced.xml 0 → 100644
<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Version Major="5" Minor="0" Point="0"/>
</SimBiology>
</annotation>
<model id="mwd1aff84f_aa0e_40d8_93cb_8b1e82aabb9c" name="model_Peng2016_reduced">
<listOfCompartments>
<compartment id="mw921d2d9f_ac6c_403b_b004_58f71c2a46a7" name="unnamed" size="1"/>
</listOfCompartments>
<listOfSpecies>
<species id="mwcb854aea_1d8c_42dd_9835_cf164faaaec5" name="A" compartment="mw921d2d9f_ac6c_403b_b004_58f71c2a46a7" initialAmount="1"/>
<species id="mwac0a0ebe_1235_4903_960f_26219fb3e64e" name="X1" compartment="mw921d2d9f_ac6c_403b_b004_58f71c2a46a7" initialAmount="1"/>
<species id="mwf023b580_6662_485c_a301_8d956bd8fa79" name="C2" compartment="mw921d2d9f_ac6c_403b_b004_58f71c2a46a7" initialAmount="1"/>
<species id="mwa3791413_b4bc_4277_86a2_b5ba236bbf84" name="X2" compartment="mw921d2d9f_ac6c_403b_b004_58f71c2a46a7" initialAmount="0"/>
<species id="mw794007c2_8f38_4c8a_b1e2_b463d317ddd0" name="D_m" compartment="mw921d2d9f_ac6c_403b_b004_58f71c2a46a7" initialAmount="1"/>
<species id="mwe27cfae1_815c_4f46_8a35_c2e40c7ef73d" name="R2" compartment="mw921d2d9f_ac6c_403b_b004_58f71c2a46a7" initialAmount="1"/>
<species id="mw80d2dd2b_1969_4e11_aa49_7ab8a1f8de4f" name="C1" compartment="mw921d2d9f_ac6c_403b_b004_58f71c2a46a7" initialAmount="1"/>
<species id="mw943b4d97_f644_43b1_b98d_5effad6f76e4" name="R1" compartment="mw921d2d9f_ac6c_403b_b004_58f71c2a46a7" initialAmount="1"/>
<species id="mw15d2ad36_969c_4e1d_bede_16ea29c1f8f5" name="I2" compartment="mw921d2d9f_ac6c_403b_b004_58f71c2a46a7" initialAmount="1"/>
<species id="mwd782f941_4588_47f4_92eb_52eaaacfbf27" name="D_C" compartment="mw921d2d9f_ac6c_403b_b004_58f71c2a46a7" initialAmount="1"/>
<species id="mw007d8f69_2cbb_4dec_9d6a_f66fbc1c7699" name="D_R" compartment="mw921d2d9f_ac6c_403b_b004_58f71c2a46a7" initialAmount="1"/>
<species id="mw16653110_92b3_445e_998d_a9092b33acdb" name="I1" compartment="mw921d2d9f_ac6c_403b_b004_58f71c2a46a7" initialAmount="1"/>
</listOfSpecies>
<listOfParameters>
<parameter id="mw10524103_4b8d_4d58_ba64_21a7cd6caceb" name="lambda_A" value="0.6931"/>
<parameter id="mw111cd5af_c900_4add_b087_ed7eab88c8a2" name="r_p1" value="0.323432"/>
<parameter id="mw57f96346_7018_4618_9ad7_b848f0049758" name="r_a1" value="0.1"/>
<parameter id="mwcc3b82a6_b294_4093_aee3_acb497d28799" name="r_m" value="6.702665"/>
<parameter id="mw896a74fe_e7f3_4288_bbf5_9f170fb52364" name="k_cx" value="0.1"/>
<parameter id="mwf4815c77_2076_4e99_bed9_1a547ae707e1" name="r_p2" value="1.426189"/>
<parameter id="mw062c135d_106d_469e_8b29_764700e7cf9d" name="r_a2" value="1.061691"/>
<parameter id="mw7426f64c_66e9_4af1_8a57_4295a705bd95" name="alpha_XD" value="2.096368"/>
<parameter id="mw075a80d7_b6de_4461_bf1c_ad653afa7601" name="pigreco_D" value="5.051123"/>
<parameter id="mw30638d26_d68a_4a49_9459_1d0df0cdfc66" name="alpha_DC" value="3.077551"/>
<parameter id="mw7ab1077a_da83_482d_8b97_d5eed490d2eb" name="pigreco_C" value="4.111938"/>
<parameter id="mwf8ac444d_dd44_4875_a5fa_d0a59f54f9d7" name="k_RC" value="1.459617"/>
<parameter id="mw00bae417_f492_440b_b7eb_eb1e4290acc5" name="mi_C" value="0.978832"/>
<parameter id="mwe22c23d9_d0d3_43e1_b252_b9d2bc3658b0" name="alpha_DR" value="0.739121"/>
<parameter id="mw172f7f7a_da90_4cf9_952d_cf5a821be0d3" name="pigreco_R" value="0.1"/>
<parameter id="mw38d229af_206b_4608_b1e6_0d997a37adcb" name="alpha_IR" value="0.354526"/>
<parameter id="mw717f6720_59c9_4d01_b7c6_3358c452b126" name="alpha_XR" value="0.144144"/>
<parameter id="mw48fc3924_91f6_4185_8351_3229405e91c5" name="mi_R" value="0.564691"/>
<parameter id="mw1b922bf8_b86e_4396_a699_cc0b3198c237" name="alpha_CI" value="0.408862"/>
<parameter id="mw3b3518fc_bf4a_4d2e_9011_c8cb13d0a742" name="mi_I" value="0.213819"/>
<parameter id="mwf23c059e_693b_4e70_9d91_3642da08986f" name="alpha_DCDR" value="0.1"/>
<parameter id="mw0fc9b90d_b913_4490_b243_347abb109310" name="mi_D" value="0.650308"/>
<parameter id="mwffa50af0_25fe_485b_a927_ddae1f51af66" name="alpha_DRR" value="0.4722"/>
</listOfParameters>
<listOfReactions>
<reaction id="mwff4ae8c0_20c8_43f4_a537_e04a401af5e6" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mwcb854aea_1d8c_42dd_9835_cf164faaaec5"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> mw10524103_4b8d_4d58_ba64_21a7cd6caceb </ci>
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> mwcb854aea_1d8c_42dd_9835_cf164faaaec5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwefcec6a7_2ba0_4b73_b95d_5c730582e796" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mwac0a0ebe_1235_4903_960f_26219fb3e64e"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci> mw111cd5af_c900_4add_b087_ed7eab88c8a2 </ci>
<ci> mwcb854aea_1d8c_42dd_9835_cf164faaaec5 </ci>
<ci> mwac0a0ebe_1235_4903_960f_26219fb3e64e </ci>
</apply>
<apply>
<times/>
<ci> mw57f96346_7018_4618_9ad7_b848f0049758 </ci>
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> mwcb854aea_1d8c_42dd_9835_cf164faaaec5 </ci>
</apply>
<ci> mwac0a0ebe_1235_4903_960f_26219fb3e64e </ci>
</apply>
</apply>
<apply>
<times/>
<ci> mwcc3b82a6_b294_4093_aee3_acb497d28799 </ci>
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> mwcb854aea_1d8c_42dd_9835_cf164faaaec5 </ci>
</apply>
<ci> mwac0a0ebe_1235_4903_960f_26219fb3e64e </ci>
</apply>
</apply>
<apply>
<times/>
<ci> mw896a74fe_e7f3_4288_bbf5_9f170fb52364 </ci>
<ci> mwf023b580_6662_485c_a301_8d956bd8fa79 </ci>
<ci> mwac0a0ebe_1235_4903_960f_26219fb3e64e </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw92053dfe_0e87_4eb2_9dfc_cd88f91dadae" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mwa3791413_b4bc_4277_86a2_b5ba236bbf84"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci> mwf4815c77_2076_4e99_bed9_1a547ae707e1 </ci>
<ci> mwa3791413_b4bc_4277_86a2_b5ba236bbf84 </ci>
</apply>
<apply>
<times/>
<ci> mw062c135d_106d_469e_8b29_764700e7cf9d </ci>
<ci> mwa3791413_b4bc_4277_86a2_b5ba236bbf84 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> mwcc3b82a6_b294_4093_aee3_acb497d28799 </ci>
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> mwcb854aea_1d8c_42dd_9835_cf164faaaec5 </ci>
</apply>
<ci> mwac0a0ebe_1235_4903_960f_26219fb3e64e </ci>
</apply>
</apply>
<apply>
<times/>
<ci> mw896a74fe_e7f3_4288_bbf5_9f170fb52364 </ci>
<ci> mwf023b580_6662_485c_a301_8d956bd8fa79 </ci>
<ci> mwa3791413_b4bc_4277_86a2_b5ba236bbf84 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwc580cc57_1008_4234_baed_a7120b2c180f" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mw794007c2_8f38_4c8a_b1e2_b463d317ddd0"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mw7426f64c_66e9_4af1_8a57_4295a705bd95 </ci>
<apply>
<plus/>
<apply>
<times/>
<ci> mw57f96346_7018_4618_9ad7_b848f0049758 </ci>
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> mwcb854aea_1d8c_42dd_9835_cf164faaaec5 </ci>
</apply>
<ci> mwac0a0ebe_1235_4903_960f_26219fb3e64e </ci>
</apply>
<apply>
<times/>
<ci> mw896a74fe_e7f3_4288_bbf5_9f170fb52364 </ci>
<ci> mwf023b580_6662_485c_a301_8d956bd8fa79 </ci>
<ci> mwac0a0ebe_1235_4903_960f_26219fb3e64e </ci>
</apply>
<apply>
<times/>
<ci> mw062c135d_106d_469e_8b29_764700e7cf9d </ci>
<ci> mwa3791413_b4bc_4277_86a2_b5ba236bbf84 </ci>
</apply>
<apply>
<times/>
<ci> mw896a74fe_e7f3_4288_bbf5_9f170fb52364 </ci>
<ci> mwf023b580_6662_485c_a301_8d956bd8fa79 </ci>
<ci> mwa3791413_b4bc_4277_86a2_b5ba236bbf84 </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> mw075a80d7_b6de_4461_bf1c_ad653afa7601 </ci>
<ci> mw794007c2_8f38_4c8a_b1e2_b463d317ddd0 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw6e2f291d_34b0_4f39_a995_b096ceaa23b1" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mwf023b580_6662_485c_a301_8d956bd8fa79"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> mw30638d26_d68a_4a49_9459_1d0df0cdfc66 </ci>
<ci> mw794007c2_8f38_4c8a_b1e2_b463d317ddd0 </ci>
</apply>
<apply>
<times/>
<cn> 0.5 </cn>
<ci> mw7ab1077a_da83_482d_8b97_d5eed490d2eb </ci>
<ci> mw80d2dd2b_1969_4e11_aa49_7ab8a1f8de4f </ci>
</apply>
</apply>
<apply>
<times/>
<ci> mwf8ac444d_dd44_4875_a5fa_d0a59f54f9d7 </ci>
<ci> mwe27cfae1_815c_4f46_8a35_c2e40c7ef73d </ci>
<ci> mwf023b580_6662_485c_a301_8d956bd8fa79 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> mw00bae417_f492_440b_b7eb_eb1e4290acc5 </ci>
<ci> mwf023b580_6662_485c_a301_8d956bd8fa79 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw25cf987a_3430_40a5_9eb7_93f813aa1fd7" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mwe27cfae1_815c_4f46_8a35_c2e40c7ef73d"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> mwe22c23d9_d0d3_43e1_b252_b9d2bc3658b0 </ci>
<ci> mw794007c2_8f38_4c8a_b1e2_b463d317ddd0 </ci>
</apply>
<apply>
<times/>
<cn> 0.5 </cn>
<ci> mw172f7f7a_da90_4cf9_952d_cf5a821be0d3 </ci>
<ci> mw943b4d97_f644_43b1_b98d_5effad6f76e4 </ci>
</apply>
<apply>
<times/>
<ci> mw38d229af_206b_4608_b1e6_0d997a37adcb </ci>
<ci> mw15d2ad36_969c_4e1d_bede_16ea29c1f8f5 </ci>
</apply>
<apply>
<times/>
<ci> mw717f6720_59c9_4d01_b7c6_3358c452b126 </ci>
<apply>
<plus/>
<ci> mwac0a0ebe_1235_4903_960f_26219fb3e64e </ci>
<ci> mwa3791413_b4bc_4277_86a2_b5ba236bbf84 </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> mw48fc3924_91f6_4185_8351_3229405e91c5 </ci>
<ci> mwe27cfae1_815c_4f46_8a35_c2e40c7ef73d </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw4bb15e69_86f7_41a6_a368_4b8481acbb4f" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mw15d2ad36_969c_4e1d_bede_16ea29c1f8f5"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mw1b922bf8_b86e_4396_a699_cc0b3198c237 </ci>
<ci> mwf023b580_6662_485c_a301_8d956bd8fa79 </ci>
</apply>
<apply>
<times/>
<ci> mw3b3518fc_bf4a_4d2e_9011_c8cb13d0a742 </ci>
<ci> mw15d2ad36_969c_4e1d_bede_16ea29c1f8f5 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwb3396d55_3e67_4bee_b5f9_12861d7e9ff4" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mwd782f941_4588_47f4_92eb_52eaaacfbf27"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<cn> 0.5 </cn>
<ci> mw075a80d7_b6de_4461_bf1c_ad653afa7601 </ci>
<ci> mw794007c2_8f38_4c8a_b1e2_b463d317ddd0 </ci>
</apply>
<apply>
<times/>
<ci> mwf23c059e_693b_4e70_9d91_3642da08986f </ci>
<ci> mwd782f941_4588_47f4_92eb_52eaaacfbf27 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwd06aa4b5_ec2b_4f42_bacd_9a9b48232f08" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mw007d8f69_2cbb_4dec_9d6a_f66fbc1c7699"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mwf23c059e_693b_4e70_9d91_3642da08986f </ci>
<ci> mwd782f941_4588_47f4_92eb_52eaaacfbf27 </ci>
</apply>
<apply>
<times/>
<ci> mw0fc9b90d_b913_4490_b243_347abb109310 </ci>
<ci> mw007d8f69_2cbb_4dec_9d6a_f66fbc1c7699 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwcba0059f_ead9_46ed_b835_b087776d90bb" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mw80d2dd2b_1969_4e11_aa49_7ab8a1f8de4f"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci> mw30638d26_d68a_4a49_9459_1d0df0cdfc66 </ci>
<ci> mwd782f941_4588_47f4_92eb_52eaaacfbf27 </ci>
</apply>
<apply>
<times/>
<ci> mw00bae417_f492_440b_b7eb_eb1e4290acc5 </ci>
<ci> mw80d2dd2b_1969_4e11_aa49_7ab8a1f8de4f </ci>
</apply>
</apply>
<apply>
<times/>
<ci> mwf8ac444d_dd44_4875_a5fa_d0a59f54f9d7 </ci>
<ci> mw943b4d97_f644_43b1_b98d_5effad6f76e4 </ci>
<ci> mw80d2dd2b_1969_4e11_aa49_7ab8a1f8de4f </ci>
</apply>
</apply>
<apply>
<times/>
<ci> mw7ab1077a_da83_482d_8b97_d5eed490d2eb </ci>
<ci> mw80d2dd2b_1969_4e11_aa49_7ab8a1f8de4f </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mw990695d1_0eb2_4b33_9501_9f1a8492651b" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mw943b4d97_f644_43b1_b98d_5effad6f76e4"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> mwffa50af0_25fe_485b_a927_ddae1f51af66 </ci>
<ci> mw007d8f69_2cbb_4dec_9d6a_f66fbc1c7699 </ci>
</apply>
<apply>
<times/>
<ci> mw38d229af_206b_4608_b1e6_0d997a37adcb </ci>
<ci> mw16653110_92b3_445e_998d_a9092b33acdb </ci>
</apply>
</apply>
<apply>
<times/>
<ci> mw48fc3924_91f6_4185_8351_3229405e91c5 </ci>
<ci> mw943b4d97_f644_43b1_b98d_5effad6f76e4 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> mw172f7f7a_da90_4cf9_952d_cf5a821be0d3 </ci>
<ci> mw943b4d97_f644_43b1_b98d_5effad6f76e4 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="mwba6904ea_8814_4646_a23c_446eb09e07f6" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="mw16653110_92b3_445e_998d_a9092b33acdb"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> mw1b922bf8_b86e_4396_a699_cc0b3198c237 </ci>
<ci> mw80d2dd2b_1969_4e11_aa49_7ab8a1f8de4f </ci>
</apply>
<apply>
<times/>
<ci> mw3b3518fc_bf4a_4d2e_9011_c8cb13d0a742 </ci>
<ci> mw16653110_92b3_445e_998d_a9092b33acdb </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>
Styling with Markdown is supported
You are about to add 0 people to the discussion. Proceed with caution.
Finish editing this message first!